Scabutol-50
| Category | Cardio Product Range |
|---|---|
| Brand Name | Scabutol-50 |
| Composition | Sacubitril 24mg + Valsartan 26mg Tablet |
| Packing | 10X14 Alu Alu |
Sacubitril / Valsartan Tablets
Sacubitril and Valsartan tablets are used to treat heart failure. This innovative medication brings together two distinct mechanisms of action to effectively manage heart failure with reduced ejection fraction (HFrEF), offering patients a new ray of hope for improved cardiac health.
Sacubitril:
Sacubitril is a neprilysin inhibitor that works by blocking an enzyme responsible for breaking down beneficial peptides in the heart. By inhibiting neprilysin, Sacubitril increases the levels of these peptides, which have vasodilatory, diuretic, and natriuretic effects. This leads to the relaxation and dilation of blood vessels, reducing the workload on the heart and improving overall cardiac function. Sacubitril contributes to symptomatic relief and helps enhance the patient’s quality of life
Valsartan:
Valsartan is an angiotensin receptor blocker (ARB) that acts on the renin-angiotensin-aldosterone system (RAAS). By blocking the action of angiotensin II on blood vessels and adrenal glands, Valsartan promotes vasodilation and reduces blood pressure. Additionally, it helps prevent the adverse remodelling of the heart muscles that often occurs in heart failure. Valsartan’s ability to modulate the RAAS system plays a crucial role in managing the progression of heart failure.
Important Consideration
Sacubitril/Valsartan Tablets are medications that can only be prescribed by a doctor for the management of chronic heart failure with reduced ejection fraction (HFrEF).
- It must only be administered under the guidance of a cardiologist or physician
- It cannot be used as a general drug for hypertension
- It is used for modifying heart failure
This medicine should never be taken in combination with ACE inhibitors
Note: At least 36 hours must elapse between stopping an ACE inhibitor and starting sacubitril/valsartan tablets to prevent angioedema.
Clinical Role
Sacubitril/Valsartan is an evidence-based first-line treatment option in the management of:
- Heart Failure with Reduced Ejection Fraction (HFrEF)
- NYHA Class II to IV
It is endorsed by key cardiological practice guidelines (AHA/ACC, ESC) as an alternative to ACE inhibitors or ARBs in appropriate cases.
HOW SACUBITRIL / VALSARTAN WORKS
This medicine combines two complementary mechanisms:
Sacuitril (Neprilysin Inhibitor)
Blocks neprilysin enzyme
Increases beneficial natriuretic peptides
Leads to:
- Vasodilation
- Reduced sodium and fluid retention
- Decreased cardiac stress
Valsartan (ARB – Angiotensin II Blocker)
Blocks angiotensin II receptors
Leads to:
- Lower blood pressure
- Reduced vasoconstriction
- Prevention of cardiac remodeling
Combined Effect:
- Improves heart efficiency
- Reduces strain on the heart
- Slows disease progression
- Improves survival outcomes
How to use Sacubitril and Valsartan Tablets?
- Follow the specific amount and instructions given by your healthcare provider.
- Take this medication every day at the same time to ensure that the levels of the medication in your body remain steady.
- Swallow the tablet with water and do not smash or bite it.
- Follow the instructions on whether to take it with or without food as recommended.
- If you forget to take your medication, take it as soon as you remember. However, do not take an extra dose to make up for the missed one.
Benefits of Sacubitril and Valsartan Tablets:
Enhanced Cardiac Function: The combination improves heart function by promoting vasodilation and reducing fluid retention.
Reduced Mortality and Hospitalizations: Clinical trials show a significant decrease in cardiovascular mortality and heart failure-related hospitalizations.
Symptomatic Relief: Patients experience relief from symptoms like shortness of breath and fatigue, leading to improved daily comfort.
Slowed Disease Progression: Adverse cardiac remodelling is slowed, preserving heart function and potentially delaying interventions.
Simplified Regimen: Combining two mechanisms of action in one tablet streamlines treatment and enhances adherence.
Improved Quality of Life: Symptom relief and better cardiac health contribute to an enhanced overall quality of life.
Recognised Efficacy: Approved by authorities and endorsed in clinical guidelines, indicating proven efficacy and safety.
Side effects
- Low Blood Pressure
- High Potassium
- Kidney Effects
- Cough
- Angioedema
- Uric Acid
- Diarrhea
- Fatigue
- Allergic
Important Warnings
Do not use this medicine if:
- You are pregnant
- You have a history of angioedema
- You are currently using ACE inhibitors
Serious risks include:
- Severe low blood pressure
- High potassium
- Kidney function worsening
- Andoedema
Monitoring Requirements
Any patient that is on Sacubitril/Valsartan should go through regular monitoring:
- Blood pressure
- Serum potassium levels
- Kidney function (creatinine / eGFR)
- Signs of fluid retention or dehydration
Drug Interactions
Avoid or use caution with:
- ACE inhibitors
Potassium supplements or potassium sparing diuretics - NSAIDs
- Lithium
- Other ARBs
Pregnancy & Breastfeeding
- Should not be used during pregnancy because of risk of fetal toxicity
- Should be avoided while nursing unless directed by a doctor
- Another treatment should be explored for pregnant women
Frequently Asked Questions
Q1. What is Sacubitril/Valsartan used for?
Sacubitril/Valsartan is used to treat chronic heart failure with reduced ejection fraction. It helps to improve heart function and reduce symptoms. This lowers the risk of hospitalisation and death.
Q2. Can Sacubitril/Valsartan replace ACE inhibitors?
Yes, it is many times prescribed as a replacement for ACE inhibitors or ARBs in eligible patients. You have to maintain a 36-hour gap when you’re switching from an ACE inhibitor.
Q3. How long does Sacubitril/Valsartan take to work?
You may see some symptom improvement within a few weeks, but full benefits, including reduced hospitalization risk, occur with long-term use.
Q4. Can I take Sacubitril/Valsartan for high blood pressure alone?
No, it is mostly indicated for heart failure and is not recommended as a routine treatment for hypertension alone unless and until it is prescribed by a doctor.
Q5. What should I avoid while taking Sacubitril/Valsartan?
You should avoid potassium supplements, any salt substitutes that contain potassium, NSAIDs and alcohol. Also, do not take it with ACE inhibitors.
Q6. What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it is close to your next dose, skip the missed one. Do not take a double dose.
Q7. Is Sacubitril/Valsartan safe during pregnancy?
No, it’s not meant to be used during pregnancy as that may cause serious harm to the unborn baby.
